Students with disabilities experience (SWDS) difficulties in learning due to limitations placed on them by their defect. To meet their learning needs distinguishing educational provisions from regular education were introduced into educational system which consist of special teachers and modification of curriculum, instructional procedures, methodology, instructional materials and learning environment contingent on category and magnitude of disabilities. Similarly, given that learning has to be effective; inclusive education in regular educational institutions was introduced. Nevertheless, while those who cannot benefit from inclusive education due to the severity of their handicap; provisions were made to accommodate them in special classes and special schools. These provisions are indeed beneficial to SWDs. However, introduction of Artificial Intelligence (AI) in tertiary institutions personalizes and has been found to enhance learning for SWDs. Moreover, its use is not without challenges which need to be addressed to enable them benefit maximally from this novel and unique technology. This paper, therefore, through evaluative and prescriptive methodology using google search on the theme, concepts and keywords examines the type of AI technologies used by SWDs in higher education, benefits and challenges. Finally, the paper offers some suggestions on overcoming these challenges to enable SWDs benefit maximally from the usage.