This study examined Socio-cultural factors on antisocial behaviour among students of tertiary institutions in Cross River State, Nigeria. To guide the study, two hypotheses were tested. The study adopted descriptive survey research design. The population of the study is 74,847 consisting of all students of public tertiary institutions in Cross River State., 1000 students was drawn using proportionate sampling technique. A questionnaire was used as instrument for the study. Mean and standard deviation was used to answer research questions while Regression and ANOVA was used to test hypotheses. The study also indicated that that a rise in cultural values will lead to a decrease in anti-social behaviour. This implies that when students are morally right, their tendencies of being involved in anti-social behaviours will reduce, students who belong to African traditional religion worshipper’s group are prone to engage in actions and inactions that are regarded as anti, followed by the Muslims and the Christians. The study recommends that government should entrench through the instrument of education, the inculcation of the right type of values at the different stages of learning and religious leaders should use their platforms to preach and send a message of change, especially to students who are manifesting the signs of antisocial behaviour. This should be done with love.