Currently there is an increase in psychiatric, chronic-degenerative diseases, which is surrounded by little visibility and taboos that flood society. This study was carried out with a sample of 25 informal caregivers of users with a mental illness, where the caregiver is in the age range between 18 and 70 years. It was carried out with a qualitative, descriptive approach, where the perception of primary caregivers was known through a semi-structured interview, the results showed that excess burden has a direct effect on the quality of life of the caregiver, finding high levels of stress, anxiety, depression, this expressed in the behavior of the interviewees, in addition to physical injuries directly related to the care burden.To lighten the burden of care, nursing staff must be responsible for establishing effective strategies that provide tools to form favorable environments for caregivers. This will help reduce the burden and improve the quality of life, creating integrity among the caregivers. caregiver and patient, focusing on the strengths of the sick person and the family, as well as obtaining more information about the care that a mental illness entails and the resources that exist in the community, creating a supportive environment, improving skills coping skills of primary caregivers.